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Side Effects Get emergency medical help if you have any of these signs of an allergic reaction to Generic Estradiol: In addition, mammography examinations should be scheduled based on patient age, risk factors, and prior mammogram results. Among women who reported prior use of hormone therapy, the relative risk of invasive breast cancer was 1. Special Populations No pharmacokinetic studies were conducted in special populations, including patients with renal or hepatic impairment. Exacerbation Of Other Conditions Estrogens may cause an exacerbation of asthma , diabetes mellitus, epilepsy , migraine or porphyria , systemic lupus erythematosus, and hepatic hemangiomas and should be used with caution in women with these conditions. Reduced response to metyrapone test. Herbs for Estrogen Dominance.